Progressive Supranuclear Palsy: Subcortical Tau Depositions Are Associated with Cortical Perfusion in Frontal and Limbic Regions-Reference-Cited by-同舟云学术

Progressive Supranuclear Palsy: Subcortical Tau Depositions Are Associated with Cortical Perfusion in Frontal and Limbic Regions

Published:2024-09-03 Issue:6 Volume:14 Page:1271-1276
ISSN:1877-7171
Container-title:Journal of Parkinson's Disease
language:
Short-container-title:JPD

Author:

Theis Hendrik¹²,Barbe Michael T.²,Drzezga Alexander¹³⁴,Fink Gereon R.²⁵,Neumaier Bernd⁶⁷,Bischof Gérard N.¹⁴,van Eimeren Thilo¹²

Affiliation:

1. Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany

2. Department of Neurology, University Hospital of Cologne, Cologne, Germany

3. German Center for Neurodegenerative Diseases (DZNE), Gottingen, Germany

4. Institute for Neuroscience and Medicine (INM-2), Research Center Jülich, Jülich, Germany

5. Institute for Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany

6. Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne, Cologne, Germany

7. Institute of Neuroscience & Medicine (INM-5), Nuclear Chemistry, Research Center Jülich, Jülich, Germany

Abstract

In progressive supranuclear palsy (PSP), subcortical tau and cortical perfusion can be assessed using the tracer [18F]PI-2620. We investigated if subcortical tau (globus pallidus internus, dentate nucleus) and frontal/limbic perfusion correlate in a cohort of 32 PSP patients. Tau in subcortical regions showed significant negative correlation with perfusion in limbic cortex. Perfusion in frontal regions was negatively associated with tau in both subcortical regions, but the significance threshold was only passed for the dentate nucleus. A reason could be a diaschisis-like phenomenon; that is, subcortical tau could lead to reduced connectivity to frontal regions and, thereby, to decreased perfusion.

Publisher

IOS Press

Reference10 articles.

1. Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy;Roemer;Acta Neuropathol,2022

2. Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury;Beyer;Eur J Nucl Med Mol Imaging,2020

3. Clinical routine FDG-PET imaging of suspected progressive supranuclear palsy and corticobasal degeneration: a gatekeeper for subsequent tau-PETimaging?;Beyer;Front Neurol,2018

4. Assessment of 18F-PI-2620 as a biomarker in progressive supranuclear palsy;Brendel;JAMA Neurol,2020

5. Impact of tau and amyloid burden on glucose metabolism in Alzheimer’s disease;Bischof;Ann Clin Transl Neurol,2016