Are Preformed Fibrils a Model of Parkinson’s Disease?

Abstract

 Pre-formed fibrils (PFFs) made from recombinant α-synuclein are broadly used throughout the field in cellular and animal models of Parkinson’s disease. However, their ability to successfully recapitulate disease biology is a controversial topic. In this article, two researchers debate this issue with Amanda Woerman taking the view that PFFs are a model of synucleinopathy but not Parkinson’s disease, while Kelvin Luk defends their use as an important tool in the field.