A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer’s Disease Brains

Author:

Haddick Patrick C.G.1,Larson Jessica L.2,Rathore Nisha3,Bhangale Tushar R.3,Phung Qui T.4,Srinivasan Karpagam5,Hansen David V.5,Lill Jennie R.4,Pericak-Vance Margaret A.67,Haines Jonathan8,Farrer Lindsay A.910111213,Kauwe John S.14,Schellenberg Gerard D.15,Cruchaga Carlos1617,Goate Alison M.1819,Behrens Timothy W.3,Watts Ryan J.5,Graham Robert R.3,Kaminker Joshua S.2,van der Brug Marcel1,

Affiliation:

1. Department of Diagnostic Discovery, Genentech Inc., South San Francisco, CA, USA

2. Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA, USA

3. Department of Human Genetics, Genentech Inc., South San Francisco, CA, USA

4. Department of Protein Chemistry, Genentech Inc., South San Francisco, CA, USA

5. Department of Neuroscience, Genentech Inc., South San Francisco, CA, USA

6. The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA

7. Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA

8. Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA

9. Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine and Public Health, Boston, MA, USA

10. Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA, USA

11. Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA, USA

12. Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA

13. Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA

14. Department of Biology, Brigham Young University, Provo, UT, USA

15. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

16. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

17. Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA

18. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York City, NY, USA

19. Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York City, NY, USA

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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