Refining Risk for Alzheimer’s Disease Among Heterozygous APOE ɛ4 Carriers-Reference-Cited by-同舟云学术

Refining Risk for Alzheimer’s Disease Among Heterozygous APOE ɛ4 Carriers

Published:2023-07-18 Issue:2 Volume:94 Page:483-489
ISSN:1387-2877
Container-title:Journal of Alzheimer's Disease
language:
Short-container-title:JAD

Author:

Patel Smita¹,Wei Jun²,Shi Zhuqing²,Rifkin Andrew S.²,Zheng S. Lilly²,Gelfman Elizabeth³,Duggan David⁴,Helfand Brian T.²⁵,Hulick Peter J.⁶,Xu Jianfeng²⁵

Affiliation:

1. Department of Neurology, NorthShore University HealthSystem, Evanston, IL, USA

2. Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA

3. Northwestern Feinberg School of Medicine, Chicago, IL, USA

4. Translational Genomics Research Institute, Part of City of Hope, Phoenix, AZ, USA

5. University of Chicago Pritzker School of Medicine, Chicago, IL, USA

6. Neaman Center for Personalized Medicine, NorthShore University HealthSystem, Evanston, IL, USA

Abstract

In a large population-based cohort, we show not all heterozygous APOE ɛ4 carriers are at increased risk for Alzheimer’s disease (AD); a significantly higher AD proportion was only found for ɛ3/ɛ4, not ɛ2/ɛ4. Among ɛ3/ɛ4 carriers (24% in the cohort), the AD proportion differed considerably by polygenic risk score (PRS). In particular, the AD proportion was lower than the entire cohort for subjects in the bottom 20-percentile PRS and was higher than that of homozygous ɛ4 carriers for subjects at the top 5th-percentile PRS. Family history was no longer a significant predictor of AD risk after adjusting APOE and PRS.

Publisher

IOS Press

Subject

Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,General Medicine,General Neuroscience

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