The Role of Cerebellum in Alzheimer’s Disease: A Forgotten Research Corner

Abstract

Alzheimer’s disease (AD) is a complex, heterogeneous, and progressive neurodegenerative dementia. Although the majority of AD research has primarily focused on disease-associated alterations of the cortex and hippocampus in the cerebrum, emerging evidence has highlighted the cerebellum’s involvement in sleep, cognition, and AD. In this commentary, we discuss a recently published article in Alzheimer’s and Dementia, which examines changes in cerebellar electrophysiology, sleep-wake cycles, and neuropathology in APPswe/PS1ΔE9 mice. We also explore the potential role of the cerebellum in AD, offering a fresh perspective on the study of cerebellar involvement in the disease.