Dose-Response Relationships of Resistance Training in Adults With Knee Osteoarthritis: A Systematic Review and Meta-analysis

Author:

Wang Huan1,Ma Baoan1,Wang Guotuan2,Wang Pu1,Long Hua1,Niu Shun1,Dong Chuan1,Zhang Hongtao1,Zhao Zhen1,Ma Qiong1,Hsu Chihw-Wen34,Yang Yong2ORCID,Wei Jianshe25

Affiliation:

1. Department of Orthopedics, Tangdu Hospital of Air Force Military Medical University, Xi'ep, China.

2. Laboratory of Kinesiology and Rehabilitation, School of Physical Education and Sport, Chaohu University, Hefei 238000, China.

3. General Education Center, National Taiwan Sport University, Taoyuan, Taiwan.

4. Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan, Taiwan.

5. Institute for Brain Sciences Research, School of Life Sciences, Henan University, Kaifeng, China.

Abstract

Background and Purpose: To determine the effects of resistance training (RT) on symptoms, function, and lower limb muscle strength in patients with knee osteoarthritis (KOA), and to determine the optimal dose-response relationships. Data Sources: We searched the PubMed, MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and ClinicalTrials.gov databases from inception to January 23, 2022. Eligibility Criteria: Randomized controlled trials that examined the effects of RT in KOA patients (mean age ≥50 years) were included. Data Synthesis: We applied Hedges' g of the random-effects model to calculate the between-subject standardized mean difference (SMDbs). A random-effects metaregression was calculated to explain the influence of key training variables on the effectiveness of RT. We used the Grading of Recommendations Assessments, Development and Evaluation (GRADE) method to appraise the certainty of evidence. Results: A total of 46 studies with 4289 participants were included. The analysis revealed moderate effects of RT on symptoms and function (SMDbs =−0.52; 95% CI: −0.64 to −0.40), and lower limb muscle strength (SMDbs = 0.53; 95% CI: 0.42 to 0.64) in the intervention group compared with the control group. The results of the metaregression revealed that only the variable “training period” (P< .001) had significant effects on symptoms, function, and lower limb muscle strength, and the 4 to 8 weeks of training subgroup showed greater effects than other subgroups (SMDbs =−0.70, −0.91 to −0.48; SMDbs = 0.76, 0.56 to 0.96). Conclusions: Compared with inactive treatments, RT is strongly recommended to improve symptoms, function, and muscle strength in individuals with KOA. Dose-response relationship analysis showed that 4 to 8 weeks of RT had more benefits.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Geriatrics and Gerontology,Rehabilitation

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