Molecular Modeling and Molecular Dynamics Simulation Studies on the Selective Binding Mechanism of MTHFD2 Inhibitors
Author:
Publisher
Scientific Research Publishing, Inc.
Subject
General Medicine
Reference27 articles.
1. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
2. Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development
3. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
4. Increased MTHFD2 expression is associated with poor prognosis in breast cancer
5. Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications
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1. Exploring the Anticancer Potential of Furanpydone A: A Computational Study on its Inhibition of MTHFD2 Across Diverse Cancer Cell Lines;Cell Biochemistry and Biophysics;2024-08-07
2. Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach;Scientific Reports;2023-10-23
3. Study of the Effect of Operating Temperatures (1320 K, 1420 K and 1520 K) on the Vacant Sites of TiN Alloy in B2 Structure at 45%, 50% and 55% N by MEAM Method;Advances in Materials Physics and Chemistry;2023
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