Durable Response to Trametinib in an Infant With ERC1-BRAF Infantile Fibrosarcoma-Like Tumor: A Case Report and Literature Review of BRAF-Altered Infantile Fibrosarcoma-Like Tumors

Author:

Gourmel Antoine1,Rouette Alexandre2ORCID,Benlimame Naciba3,El-Jalbout Ramy4,Dubé Mireille5,Théorêt Yves6,Piché Nelson7ORCID,Labonté Sébastien8,Sinnett Daniel9ORCID,Cellot Sonia19ORCID,Dal-Soglio Dorothée10,Larouche Valérie11,Tran Thai Hoa19ORCID

Affiliation:

1. Division of Pediatric Hematology-Oncology, Charles-Bruneau Cancer Centre, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Université de Montreal, Montreal, QC, Canada

2. Molecular Diagnostics Laboratory, Charles-Bruneau Cancer Center, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montréal, QC, Canada

3. Research Pathology Facility, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada

4. Department of Radiology, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montreal, QC, Canada

5. Department of Medical Imaging, Centre Hospitalier Universitaire (CHU) de Québec, Québec, QC, Canada

6. Clinical Pharmacology Laboratory, OPTILAB and Research Center, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montréal, QC, Canada

7. Division of Paediatric Surgery, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montréal, QC, Canada

8. Department of Pathology, Centre Hospitalier Universitaire (CHU) de Québec, Québec, QC, Canada

9. Department of Pediatrics, Centre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Montréal, QC, Canada

10. Department of Pathology and Clinical Laboratory Medicine, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montréal, QC, Canada

11. Department of Pediatrics, Centre Mère-Enfant Soleil du Centre Hospitalier Universitaire (CHU) de Québec-Université Laval, Québec, QC, Canada

Publisher

American Society of Clinical Oncology (ASCO)

Subject

Cancer Research,Oncology

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