Efficacy and Safety of Immune Checkpoint Blockade in Patients With Li-Fraumeni Syndrome

Author:

Bottosso Michele12ORCID,Verret Benjamin13,Caron Olivier4ORCID,Hamzaoui Nadim56ORCID,Pasmant Eric56ORCID,Danlos Francois-Xavier789ORCID,Boudou-Rouquette Pascaline510,Srikaran Arunya10,Blons Hélène11ORCID,Guarneri Valentina212ORCID,Loi Sherene1314ORCID,André Fabrice13ORCID,Tlemsani Camille510ORCID

Affiliation:

1. INSERM Unit U981, Gustave Roussy Cancer Campus, Villejuif, France

2. Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy

3. Medical Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France

4. Oncogenetic Department, Institut Gustave Roussy, Villejuif, France

5. INSERM U1016, CNRS UMR8104, Université Paris Cité, CARPEM, Institut Cochin, Paris, France

6. Department of Molecular Biology, Fédération de Génétique et Médecine Génomique, Cochin Hospital, Université Paris Cité, APHP Centre, Paris, France

7. Drug Development Department, Gustave Roussy, Villejuif, France

8. INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France

9. Faculté de Médecine, Université Paris Saclay, Gif-sur-Yvette, France

10. Department of Medical Oncology, Cochin Hospital, Paris Cancer Institute CARPEM, Université Paris Cité, APHP Centre, Paris, France

11. Department of Molecular Biology, Fédération de Génétique et Médecine Génomique, European Geoges Pompidou Hospital, Université Paris Cité, APHP Centre, Paris, France

12. Medical Oncology 2, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy

13. Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia

14. The Sir Peter MacCallum Department of Medical Oncology, University of Melbourne, Melbourne, VIC, Australia

Abstract

A case series evaluating efficacy and safety of immune checkpoint blockade in Li-Fraumeni syndrome

Publisher

American Society of Clinical Oncology (ASCO)

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