Development of CaCO3 microsphere-based composite hydrogel for dual delivery of growth factor and Ca to enhance bone regeneration

Author:

Gong Yihong12345,Zhang Yiling12345,Cao Zhinan12345,Ye Feng678910,Lin Zefeng111241314,Li Yan12345ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument

2. School of Biomedical Engineering

3. Sun Yat-sen University

4. Guangzhou

5. P.R. China

6. Department of Pharmacology

7. Beijing Anzhen Hospital

8. Capital Medical University

9. Beijing Institute of Heart

10. Lung and Blood Vessel Disease

11. Department of Orthopedics

12. Guangzhou General Hospital of Guangzhou Military Command

13. China

14. Guangdong Key Laboratory of Orthopedic Technology and Implant Materials

Abstract

CaCO3 microspheres based composite hydrogel for dual delivery of BMP-2 and Ca enhanced in vitro osteogenic differentiation of BMSCs and significantly fastened bone regeneration in rabbit tibia defects.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Guangzhou Science & Technology Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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