The aspect ratio effect on the cytotoxicity of inert nano-particles flips depending on particle thickness, and is one of the reasons for the literature inconsistency-Reference-Cited by-同舟云学术

The aspect ratio effect on the cytotoxicity of inert nano-particles flips depending on particle thickness, and is one of the reasons for the literature inconsistency

Published:2022 Issue:24 Volume:4 Page:5257-5269
ISSN:2516-0230
Container-title:Nanoscale Advances
language:en
Short-container-title:Nanoscale Adv.

Author:

Brill-Karniely Yifat¹²^ORCID,Schwob Ouri¹,Benny Ofra¹^ORCID

Affiliation:

1. Institute for Drug Research, The School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 9112001, Israel

2. Institute of Animal Science, Agricultural Research Organization (ARO), The Volcani Center, Bet-Dagan, Israel

Abstract

Nanoparticle thickness makes a critical effect on the cytotoxicity: non-functionalized nano-rods thicker than 35 nm would commonly be more toxic when they are longer, however for thinner particles the longer they are the safer they would be.

Funder

Horizon 2020 Framework Programme

Israel Science Foundation

Ministry of Science and Technology, Israel

Hebrew University of Jerusalem

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NA/D2NA00453D

Reference22 articles.

1. Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods

2. Identifying Trends in Gold Nanoparticle Toxicity and Uptake: Size, Shape, Capping Ligand, and Biological Corona

3. Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells

4. Cellular Uptake and Cytotoxicity of Varying Aspect Ratios of Gold Nanorods in HeLa Cells

5. Gold nanoparticles impair autophagy flux through shape-dependent endocytosis and lysosomal dysfunction

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