Detection of nucleic acids and other low abundance components in native bone and osteosarcoma extracellular matrix by isotope enrichment and DNP-enhanced NMR-Reference-Cited by-同舟云学术

Detection of nucleic acids and other low abundance components in native bone and osteosarcoma extracellular matrix by isotope enrichment and DNP-enhanced NMR

Published:2019 Issue:46 Volume:9 Page:26686-26690
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Goldberga Ieva¹²³⁴^ORCID,Li Rui¹²³⁴,Chow Wing Ying⁵⁶⁷^ORCID,Reid David G.¹²³⁴^ORCID,Bashtanova Ulyana¹²³⁴,Rajan Rakesh¹²³⁴,Puszkarska Anna¹²³⁴,Oschkinat Hartmut⁵⁶⁷,Duer Melinda J.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Cambridge

3. Cambridge CB2 1EW

4. UK

5. Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)

6. Berlin 13125

7. Germany

Abstract

Towards elucidating their biological roles in intact tissue, DNP NMR reveals nucleic acids, and other important low abundance biomolecules in a complex biomaterial, bone, and in cancer extracellular matrix.

Funder

Medical Research Council

Leibniz-Gemeinschaft

Horizon 2020 Framework Programme

Engineering and Physical Sciences Research Council

Deutscher Akademischer Austauschdienst

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA03198G