Synthesis and anticancer activity of benzoselenophene and heteroaromatic derivatives of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI)-Reference-Cited by-同舟云学术

Synthesis and anticancer activity of benzoselenophene and heteroaromatic derivatives of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI)

Published:2017 Issue:5 Volume:15 Page:1198-1208
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mhetre Amol B.¹²³⁴,Lee Hangeun¹²³⁴,Yang Heekyoung⁵⁶⁷⁸⁴,Lee Kyoungmin⁵⁶⁷⁸⁴,Nam Do-Hyun⁵⁶⁷⁸⁴,Lim Dongyeol¹²³⁴

Affiliation:

1. Department of Chemistry

2. Sejong University

3. Seoul 143-747

4. Republic of Korea

5. Department of Neurosurgery

6. Samsung Medical Center

7. Sungkyunkwan University School of Medicine

8. Seoul

Abstract

Novel benzoselenophene analogs of duocarmycin were prepared. The anticancer activity of the butyramide analog of benzoselenophene was 120 times more potent than the corresponding indole analog.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02729F

Reference36 articles.

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