Carriers for hydrophobic drug molecules: lipid-coated hollow mesoporous silica particles, and the influence of shape and size on encapsulation efficiency

Author:

Iqbal Sumiya1ORCID,Schneider Tom-Jonas Klaus1ORCID,Truong Thanh Tung2,Ulrich-Müller Roman34,Nguyen Phuong-Hien2,Ilyas Shaista1ORCID,Mathur Sanjay1ORCID

Affiliation:

1. Institute of Inorganic and Materials Chemistry, University of Cologne, Greinstr. 6, 50939 Cologne, Germany

2. University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine; Center for Molecular Medicine Cologne, Kerpener Str. 62, 50937 Cologne, Germany

3. Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany

4. University of Cologne, Faculty of Medicine and University Hospital Cologne, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Joseph-Stelzmann-Straße 26, 50931, Cologne Germany

Abstract

Lipid-coated mesoporous silica nanocarriers demonstrate a novel approach to prolong the release of hydrophobic drugs, promising enhanced treatment efficacy with controlled delivery.

Funder

Universität zu Köln

Deutscher Akademischer Austauschdienst

Publisher

Royal Society of Chemistry (RSC)

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