Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells

Author:

Tran Chien Van12,Tran Thao Thi Phuong12,Nguyen Anh The1,Tran Loc Van1,Pham Ninh Thi1,Nguyen Luu Thi1,Nguyen Dung Thi1,Garrett Michelle D.3,Nguyen Nga Thi4,Do Thao Thi4ORCID,Serpell Christopher J.5ORCID,Tran Sung Van1

Affiliation:

1. Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay, Hanoi, Vietnam

2. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay, Hanoi, Vietnam

3. School of Biosciences, University of Kent, Stacey Building, Canterbury, Kent CT2 7NJ, UK

4. Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay, Hanoi, Vietnam

5. Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK

Abstract

Madecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.

Funder

Vietnam Academy of Science and Technology

Engineering and Physical Sciences Research Council

University of Kent

Publisher

Royal Society of Chemistry (RSC)

Reference41 articles.

1. Global burden of primary liver cancer in 2020 and predictions to 2040

2. International Agency for Research on Cancer (IARC) , https://gco.iarc.fr/today/data/factsheets/populations/704-viet-nam-fact-sheets.pdf

3. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

4. V. V.Chi , Dictionary of medicinal plants in Vietnam , Vietnam Publisher of Medicine , 2012 , vol. 2

5. Centella asiatica(L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential

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