3,4-Diaminopyrazolo[3,4-<i>d</i>]pyrimidines: a new three-component microwave-assisted synthesis and anti-leukemic properties-Reference-Cited by-同舟云学术

3,4-Diaminopyrazolo[3,4-d]pyrimidines: a new three-component microwave-assisted synthesis and anti-leukemic properties

Published:2023 Issue:16 Volume:21 Page:3432-3446
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ng Jia Hui¹^ORCID,Lim Felicia Phei Lin¹^ORCID,Tiekink Edward R. T.²^ORCID,Dolzhenko Anton V.¹³^ORCID

Affiliation:

1. School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan 47500, Malaysia

2. Research Centre for Crystalline Materials, School of Medical and Life Sciences, Sunway University, 5 Jalan Universiti, Bandar Sunway, Selangor Darul Ehsan 47500, Malaysia

3. Curtin Medical School, Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, GPO Box U1987 Perth, Western Australia 6845, Australia

Abstract

A one-pot multicomponent microwave-assisted synthesis was developed for the synthesis of pyrazolo[3,4-d]pyrimidines isosteric to adenine. Some compounds were identified as potent and selective anti-leukemic agents.

Funder

Sunway University

Ministry of Higher Education, Malaysia

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00350G

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