Gold(i)-catalyzed nucleophilic cyclization of β-monosubstituted o-(alkynyl)styrenes: a combined experimental and computational study-Reference-Cited by-同舟云学术

Gold(i)-catalyzed nucleophilic cyclization of β-monosubstituted o-(alkynyl)styrenes: a combined experimental and computational study

Published:2019 Issue:46 Volume:17 Page:9924-9932
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Virumbrales Cintia¹²³⁴⁵^ORCID,Solas Marta¹²³⁴⁵^ORCID,Suárez-Pantiga Samuel¹²³⁴⁵^ORCID,Fernández-Rodríguez Manuel A.¹²³⁴⁵^ORCID,Marín-Luna Marta⁶⁷⁸⁹^ORCID,López Carlos Silva⁶⁷⁸⁹¹⁰^ORCID,Sanz Roberto¹²³⁴⁵^ORCID

Affiliation:

1. Área de Química Orgánica

2. Departamento de Química

3. Facultad de Ciencias

4. Universidad de Burgos

5. 09001 Burgos

6. Departamento de Química Orgánica

7. Universidade de Vigo

8. 36310 Vigo

9. Spain

10. CITACA - Clúster de Investigación y Transferencia Agroalimentaria del Campus Auga

Abstract

The diastereospecific 5-endo cyclization of β-monosubstituted o-(alkynyl)styrenes to 1-functionalized-1H-indenes is reported. The regiospecific generation of a cyclopropyl gold carbene intermediate is also supported by DFT calculations.

Funder

Consejería de Educación, Junta de Castilla y León

Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB02126D

Reference64 articles.

1. Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity