Synthesis of new C-5-triazolyl-functionalized thymidine analogs and their ability to engage in aromatic stacking in DNA : DNA and DNA : RNA duplexes-Reference-Cited by-同舟云学术

Synthesis of new C-5-triazolyl-functionalized thymidine analogs and their ability to engage in aromatic stacking in DNA : DNA and DNA : RNA duplexes

Author:

Hornum Mick¹²³⁴⁵,Djukina Alevtina¹²³⁴⁵,Sassnau Ann-Katrin¹²³⁴⁵,Nielsen Poul¹²³⁴⁵

Affiliation:

1. Nucleic Acid Center

2. Department of Physics

3. Chemistry & Pharmacy

4. University of Southern Denmark

5. DK-5230 Odense

Abstract

Stacking interactions of substituted triazoles in the major groove were studied, and with a polar uracil, increased duplex stabilities were found.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

Reference44 articles.

1. M. Ahmadian and D. E.Bergstrom, in Modified Nucleosides, ed. P. Herdewijn, Wiley-VCH Verlag GmbH & Co. KGaA, 2008, pp. 249–276

3. P. P. Seth and E. E.Swayze, in Natural Products in Medicinal Chemistry, ed. S. Hanessian, Wiley-VCH Verlag GmbH & Co. KGaA, 2014, pp. 403–440

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