Enzymatic conjugation using branched linkers for constructing homogeneous antibody–drug conjugates with high potency-Reference-Cited by-同舟云学术

Enzymatic conjugation using branched linkers for constructing homogeneous antibody–drug conjugates with high potency

Published:2017 Issue:26 Volume:15 Page:5635-5642
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Anami Yasuaki¹²³⁴⁵^ORCID,Xiong Wei¹²³⁴⁵,Gui Xun¹²³⁴⁵,Deng Mi⁶⁷⁸⁹¹⁰,Zhang Cheng Cheng⁶⁷⁸⁹¹⁰,Zhang Ningyan¹²³⁴⁵,An Zhiqiang¹²³⁴⁵,Tsuchikama Kyoji¹²³⁴⁵^ORCID

Affiliation:

1. Texas Therapeutics Institute

2. The Brown Foundation Institute of Molecular Medicine

3. The University of Texas Health Science Center at Houston

4. 1881 East Road

5. Houston

6. Departments of Physiology and Developmental Biology

7. The University of Texas Southwestern Medical Center

8. 6001 Forest Park Road

9. Dallas

10. USA

Abstract

An efficient enzymatic method using branched linkers was developed for the construction of potent homogeneous antibody–drug conjugates.

Funder

University of Texas Medical School at Houston

Cancer Prevention and Research Institute of Texas

Welch Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01027C

Reference48 articles.

1. A History of Cancer Chemotherapy

2. Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry

3. Antibody Drug Conjugates for Cancer Therapy

4. Antibody-drug conjugates: recent advances in conjugation and linker chemistries

5. Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

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