Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery-Reference-Cited by-同舟云学术

Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery

Published:2019 Issue:54 Volume:55 Page:7792-7795
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Misawa Takashi¹²³⁴^ORCID,Ohoka Nobumichi⁵²³⁴,Oba Makoto⁶⁷⁸⁴^ORCID,Yamashita Hiroko¹²³⁴,Tanaka Masakazu⁶⁷⁸⁴,Naito Mikihiko⁵²³⁴,Demizu Yosuke¹²³⁴^ORCID

Affiliation:

1. Division of Organic Chemistry

2. National Institute of Health Sciences

3. Kawasaki-shi

4. Japan

5. Division of Molecular Target and Gene Therapy Products

6. Graduate School of Biomedical Sciences

7. Nagasaki University

8. Nagasaki 852-8521

Abstract

We have designed and synthesized a set of cell-penetrating foldamers (CPFs), Blocks 1–8, composed of the common amino acids Leu, Arg, and Gly, as well as the helicogenic amino acid 2-aminoisobutyric acid.

Funder

Japan Society for the Promotion of Science

Takeda Science Foundation

Japan Agency for Medical Research and Development

Naito Foundation

Terumo Foundation for Life Sciences and Arts

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC02203A

Reference30 articles.

1. Knocking down Disease with siRNAs

2. RNAi: a potential new class of therapeutic for human genetic disease

3. RNAi, a new therapeutic strategy against viral infection

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