Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy-Reference-Cited by-同舟云学术

Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy

Published:2021 Issue:3 Volume:38 Page:470-488
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Zhao Wei¹²³⁴,Cong Ying¹²³⁴,Li Hong-Mei¹²³⁴,Li Shengying¹²³⁴^ORCID,Shen Yuemao¹²³⁴^ORCID,Qi Qingsheng¹²³⁴,Zhang Youming¹²³⁴,Li Yue-Zhong¹²³⁴,Tang Ya-Jie¹²³⁴^ORCID

Affiliation:

1. State Key Laboratory of Microbial Technology

2. Shandong University

3. Qingdao 266237

4. China

Abstract

Natural product podophyllotoxin exhibited superior broad spectrum antitumor and antiviral activity. Over past 30 years, scientists devoted continuous efforts to develop druggability strategies and discover new podophyllotoxin-derived drugs.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

National Science Fund for Distinguished Young Scholars

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NP/D0NP00041H

Reference129 articles.

1. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019