A BODIPY biosensor to detect and drive self-assembly of diphenylalanine

Author:

Quan Li1234ORCID,Gu Jianhua5678,Lin Wenhai91011124ORCID,Wei Yanchun1234ORCID,Lin Yuebin1234,Liu Lei1234,Ding Hongyan1234,Pan Changjiang1234,Xie Zhigang91011124ORCID,Wu Tianfu131478

Affiliation:

1. Department of Mechanical and Material Engineering

2. Huaiyin Institute of Technology

3. Huai’an 223003

4. China

5. Electron Microscopy Core

6. Houston Methodist Research Institute

7. Houston

8. USA

9. State Key Laboratory of Polymer Physics and Chemistry

10. Changchun Institute of Applied Chemistry

11. Chinese Academy of Sciences

12. Changchun 130022

13. Department of Biomedical Engineering

14. University of Houston

Abstract

Diphenylalanine (FF), as the smallest unit and core recognition motif of β-amyloid (Aβ), could self-assemble into nanofibers, which induces an early onset of Alzheimer's disease (AD).

Funder

National Natural Science Foundation of China

Huaiyin Institute of Technology

Jiangsu Provincial Department of Education

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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