In vitro/in vivo “peeling” of multilayered aminocarboxylate gold nanoparticles evidenced by a kinetically stable 99mTc-label

Author:

Silva Francisco12345,Gano Lurdes12345,Cabral Campello Maria Paula12345,Marques Rosa12345ORCID,Prudêncio Isabel12345,Zambre Ajit6789,Upendran Anandhi1011789,Paulo António12345ORCID,Kannan Raghuraman678912

Affiliation:

1. Centro de Ciências e Tecnologias Nucleares

2. Instituto Superior Técnico

3. Universidade de Lisboa

4. 2695-066 Bobadela LRS

5. Portugal

6. Department of Radiology

7. University of Missouri-Columbia

8. Columbia

9. USA

10. Institute of Clinical and Translational Science

11. School of Medicine

12. Department of BioEngineering

Abstract

The BBN-Au-DTDTPA coating is selectively released upon interaction with glutathione (GSH), rendering this nanoplatform potentially useful for GSH-mediated drug delivery.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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