A novel class of tyrosine derivatives as dual 5-LOX and COX-2/mPGES1 inhibitors with PGE2 mediated anticancer properties-Reference-Cited by-同舟云学术

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A novel class of tyrosine derivatives as dual 5-LOX and COX-2/mPGES1 inhibitors with PGE2 mediated anticancer properties

Published:2019 Issue:2 Volume:43 Page:834-846
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Puratchikody Ayarivan¹²³⁴⁵^ORCID,Umamaheswari Appavoo¹²³⁴⁵^ORCID,Irfan Navabshan¹²³⁴⁵^ORCID,Sinha Shweta⁶⁷⁸⁹¹⁰^ORCID,Manju S. L.¹¹¹²¹³¹⁴^ORCID,Ramanan Meera⁶⁷⁸⁹¹⁰^ORCID,Ramamoorthy Gayathri⁶⁷⁸⁹¹⁰^ORCID,Doble Mukesh⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Drug Discovery and Development Research Group

2. Department of Pharmaceutical Technology

3. Bharathidasan Institute of Technology

4. Anna University

5. Tiruchirappalli

6. Bioengineering and Drug Design Lab

7. Department of Biotechnology

8. Bhupat and Jyoti Mehta School of Biosciences

9. Indian Institute of Technology

10. Madras

11. Department of Chemistry

12. Vellore Institute of Technology

13. Vellore

14. India

Abstract

Leukotriene and prostaglandin pathways are controlled by the enzymes, LOX and COX/mPGES1 respectively and are responsible for inflammatory responses.

Funder

Department of Science and Technology, Ministry of Science and Technology

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NJ/C8NJ04385J

Reference41 articles.

1. Leukotrienes

2. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

3. Epoxygenase Pathways of Arachidonic Acid Metabolism

4. Multi-target approach for natural products in inflammation

5. 5-Lipoxygenase: regulation of expression and enzyme activity

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