Computationally guided bioengineering of the active site, substrate access pathway, and water channels of thermostable cytochrome P450, CYP175A1, for catalyzing the alkane hydroxylation reaction-Reference-Cited by-同舟云学术

Computationally guided bioengineering of the active site, substrate access pathway, and water channels of thermostable cytochrome P450, CYP175A1, for catalyzing the alkane hydroxylation reaction

Published:2023 Issue:48 Volume:14 Page:14316-14326
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Taher Mohd¹^ORCID,Dubey Kshatresh Dutta²^ORCID,Mazumdar Shyamalava¹^ORCID

Affiliation:

1. Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India

2. Department of Chemistry, School of Natural Science, Shiv Nadar Institution of Eminence Delhi-NCR, NH91, Tehsil Dadri, Greater Noida, Uttar Pradesh 201314, India

Abstract

Rational design and engineering of the active pocket for access and binding of the substrate, and water channel in a thermostable cytochrome P450 enabled efficient catalysis of a longer chain alkane.

Funder

Tata Institute of Fundamental Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC02857G

Reference64 articles.

1. Industrial applications of enzyme biocatalysis: Current status and future aspects

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