Advances in stable isotope labeling: dynamic labeling for spatial and temporal proteomic analysis

Author:

Beller Nicole C.1,Hummon Amanda B.12ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA, 43210

2. Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA, 43210

Abstract

Traditional SILAC labeling has been expanded with pulsed applications to uncover a new quantitative dimension of proteomics – temporal analysis. These techniques have aided in inspiring SILAC-based temporal and spatial labeling applications.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

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4. Quantitative Proteomics by Metabolic Labeling of Model Organisms

5. Accurate quantitation of protein expression and site-specific phosphorylation

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