Keggin-type polyoxometalates as Cu(<scp>ii</scp>) chelators in the context of Alzheimer's disease-Reference-Cited by-同舟云学术

Keggin-type polyoxometalates as Cu(ii) chelators in the context of Alzheimer's disease

Published:2022 Issue:14 Volume:58 Page:2367-2370
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Atrián-Blasco Elena¹²,de Cremoux Lucie¹,Lin Xudong¹,Mitchell-Heggs Rufus¹,Sabater Laurent¹,Blanchard Sébastien³^ORCID,Hureau Christelle¹^ORCID

Affiliation:

1. LCC-CNRS, Université de Toulouse, CNRS, Toulouse, France

2. Instituto de Nanociencia y Materiales de Aragón (INMA), Consejo Superior de Investigaciones Científicas-Universidad de Zaragoza, Zaragoza 50009, Spain

3. CNRS, Institut Parisien de Chimie Moléculaire, IPCM, Sorbonne Université, 4 Place Jussieu, Paris F-75005, France

Abstract

Keggin-type POMs extract Cu(ii) from the Alzheimer's-related amyloid-β peptide. They prevent Cu(Aβ) ROS production, while ill-defined Cu(Aβ) aggregates are switched to fibrils due to Cu(POM) modulation of the apo-Aβ's assembly.

Funder

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D1CC05792H

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