A computational model predicts genetic nodes that allow switching between species-specific responses in a conserved signaling network
Author:
Affiliation:
1. Department of Mathematics
2. Ohio State University
3. Columbus
4. USA
5. Department of Molecular Genetics
6. Graduate Program in Molecular
7. Department of Statistics
Abstract
Alterations to only specific parameters in a model including EGF, Wnt and Notch lead to cell behavior differences.
Funder
Division of Mathematical Sciences
Publisher
Oxford University Press (OUP)
Subject
Biochemistry,Biophysics
Link
http://pubs.rsc.org/en/content/articlepdf/2017/IB/C6IB00238B
Reference39 articles.
1. The gene lin-3 encodes an inductive signal for vulval development in C. elegans
2. Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans
3. Wnt signal from multiple tissues and lin-3/EGF signal from the gonad maintain vulval precursor cell competence in Caenorhabditis elegans
4. Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development
5. C. elegans LIN-18 Is a Ryk Ortholog and Functions in Parallel to LIN-17/Frizzled in Wnt Signaling
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