Desilylative activation of TMSCN in chemoselective Strecker–Ugi type reaction: functional fused imidazoles as building blocks as an entry route to annulated purines-Reference-Cited by-同舟云学术

Desilylative activation of TMSCN in chemoselective Strecker–Ugi type reaction: functional fused imidazoles as building blocks as an entry route to annulated purines

Published:2014 Issue:34 Volume:12 Page:6694-6705
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Guchhait Sankar K.¹²³,Chaudhary Vikas¹²³

Affiliation:

1. Department of Medicinal Chemistry

2. National Institute of Pharmaceutical Education and Research (NIPER)

3. Mohali – 160062, India

Abstract

Nucleophilic activation of TMSCN as an isocyanide equivalent by DABCO–THF in the Strecker–Ugi reaction facilitates the synthesis of functional imidazoles which, as building blocks, afford access to C8–N9 annulated purines.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00882K

Reference37 articles.

1. The purines: Potent and versatile small molecule inhibitors and modulators of key biological targets

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4. Pyrido[2,1-f]purine-2,4-dione Derivatives as a Novel Class of Highly Potent Human A3 Adenosine Receptor Antagonists

5. Imidazo[2,1-i]purin-5-ones and Related Tricyclic Water-Soluble Purine Derivatives: Potent A2A- and A3-Adenosine Receptor Antagonists

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