Zn2+-Dependent peptide nucleic acid-based artificial ribonucleases with unprecedented efficiency and specificity-Reference-Cited by-同舟云学术

Zn2+-Dependent peptide nucleic acid-based artificial ribonucleases with unprecedented efficiency and specificity

Published:2021 Issue:83 Volume:57 Page:10911-10914
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Luige Olivia¹^ORCID,Bose Partha Pratim¹,Stulz Rouven¹²³,Steunenberg Peter¹,Brun Omar¹,Andersson Shalini²,Murtola Merita¹,Strömberg Roger¹^ORCID

Affiliation:

1. Department of Biosciences and Nutrition, Karolinska Institutet, Neo, 141 83 Huddinge, Sweden

2. Oligonucleotide Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

3. DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

Abstract

Novel efficient Zn2+ dimethyl-dipyridophenazine PNA-based artificial nucleases cleave RNA site-specifically and can be tailored to different RNA targets, including RNA models originating from a malaria parasite and the SARS-CoV-2 virus.

Funder

Horizon 2020

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC04383H

Reference38 articles.

1. Antisense technology: an overview and prospectus

2. The chemical evolution of oligonucleotide therapies of clinical utility

3. Advances in oligonucleotide drug delivery

4. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Organomercury oligonucleotide conjugates as artificial ribonucleases;Journal of Inorganic Biochemistry;2023-10

2. An RNA‐Cleaving DNAzyme That Requires an Organic Solvent to Function;Angewandte Chemie International Edition;2023-09-13

3. An RNA‐Cleaving DNAzyme That Requires an Organic Solvent to Function;Angewandte Chemie;2023-09-13

4. A copper(ii) peptide helicate selectively cleaves DNA replication foci in mammalian cells;Chemical Science;2023

5. Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications;Nucleic Acids Research;2022-05-30