Organo-photoredox catalyzed gem-difluoroallylation of ketone-derived dihydroquinazolinones via C(sp3)–C bond and C(sp3)

Organo-photoredox catalyzed gem-difluoroallylation of ketone-derived dihydroquinazolinones via C(sp³)–C bond and C(sp³)–F bond cleavage

Published:2024 Issue:27 Volume:22 Page:5561-5568
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhang Yue¹,Zhu Tianshuai¹,Lin Yuqian¹,Wei Xian¹,Xie Xinyu¹,Lin Ruofan¹,Zhang Zhijie¹,Fang Weiwei¹^ORCID,Zhang Jing-Jing¹^ORCID,Zhang Yue²^ORCID,Hu Meng-Yang³,Cai Lingchao¹^ORCID,Chen Zhen¹^ORCID

Affiliation:

1. Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing, Jiangsu, 210037, China

2. Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat-Sen), Nanjing 210014, Jiangsu, China

3. DreamChem (Tianjin) Co., Ltd., No. 4, Haitai Development 2nd Road, Binhai High-tech Zone, Tianjin, 300380, China

Abstract

An organo-photoredox catalyzed defluorinative alkylation of ketone-derived dihydroquinazolinones with α-trifluoromethyl alkenes is described, providing a facile access to a diverse set of gem-difluoroalkenes.

Funder

Basic Research Program of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00671B

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