Converting disulfide bridges in native peptides to stable methylene thioacetals-Reference-Cited by-同舟云学术

Converting disulfide bridges in native peptides to stable methylene thioacetals

Published:2016 Issue:12 Volume:7 Page:7007-7012
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kourra C. M. B. K.¹²³⁴⁵,Cramer N.¹²³⁴⁵

Affiliation:

1. Laboratory of Asymmetric Catalysis and Synthesis

2. Institute of Chemical Sciences and Engineering

3. Ecole Polytechnique Fédérale de Lausanne

4. EPFL SB ISIC LCSA

5. CH-1015 Lausanne

Abstract

A mild and simple protocol converts the labile disulfide bond of unprotected native peptides into highly stable methylene thioacetals, annihilating reductive lability and increasing stability.

Funder

Swiss National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC02285E

Reference67 articles.

1. Therapeutic peptides: technological advances driving peptides into development

2. Peptides As Therapeutics with Enhanced Bioactivity

3. Synthetic therapeutic peptides: science and market

4. Multifaceted Roles of Disulfide Bonds. Peptides as Therapeutics

5. β-Peptides: From Structure to Function

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