Analysis of the productivity of DNA encoded libraries-Reference-Cited by-同舟云学术

Analysis of the productivity of DNA encoded libraries

Published:2016 Issue:7 Volume:7 Page:1323-1331
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Eidam Oliv¹²³⁴⁵,Satz Alexander L.¹²³⁴⁵

Affiliation:

1. Roche Pharmaceutical Research and Early Development (pRED)

2. Roche Innovation Center Basel

3. F. Hoffmann-La Roche Ltd

4. CH-4070 Basel

5. Switzerland

Abstract

Analysis of physical properties and structural diversity of 57 molecules derived from screening 5–16 DNA encoded libraries against two protein targets. DNA encoded library size is not predictive of productivity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00221H

Reference30 articles.

1. Design, synthesis and selection of DNA-encoded small-molecule libraries

2. DNA-encoded chemical libraries of macrocycles

3. Novel encoding methods for DNA-templated chemical libraries

4. DNA-Encoded Solid-Phase Synthesis: Encoding Language Design and Complex Oligomer Library Synthesis

5. Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation

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