Molecular modeling of cytotoxic activity of a new terpenoid-like bischalcone-Reference-Cited by-同舟云学术

Molecular modeling of cytotoxic activity of a new terpenoid-like bischalcone

Published:2019 Issue:47 Volume:43 Page:18451-18460
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Sallum Lóide O.¹²³⁴^ORCID,Siqueira Vera L.⁵³⁴,Custodio Jean M. F.¹²³⁴^ORCID,Borges Nádia M.¹²³⁴,Lima Aliny P.⁵³⁴⁶⁷,Abreu Davi C.⁶⁷⁸⁴,S. Lacerda Elisângela de P.⁶⁷⁸⁴^ORCID,Lima Rosa S.⁵³⁴,M. de Oliveira Alisson⁵³⁴,Camargo Ademir J.¹²³⁴,Napolitano Hamilton B.¹²³⁴⁹^ORCID

Affiliation:

1. Grupo de Química Teórica e Estrutural

2. Universidade Estadual de Goiás

3. Anápolis

4. Brazil

5. Faculdade do Instituto Brasil

6. Instituto de Ciências Biológicas

7. Universidade Federal de Goiás

8. Goiânia

9. Laboratório de Novos Materiais

Abstract

This study describes the synthesis and structure of (1E,4E)-1-(3-chlorophenyl)-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-1,4-dien-3-one (BC I). This work evaluates molecular docking and cytotoxic activity against two tumor cell lines.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de Goiás

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NJ/C9NJ03452H

Reference56 articles.

1. Synthetic cyclohexenyl chalcone natural products possess cytotoxic activities against prostate cancer cells and inhibit cysteine cathepsins in vitro

2. Review of Methods and Various Catalysts Used for Chalcone Synthesis

3. Anti-allergic Activity of Naringenin Chalcone from a Tomato Skin Extract

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