Comparison of three different conjugation strategies in the construction of herceptin-bearing paclitaxel-loaded nanoparticles-Reference-Cited by-同舟云学术

Comparison of three different conjugation strategies in the construction of herceptin-bearing paclitaxel-loaded nanoparticles

Published:2016 Issue:8 Volume:4 Page:1219-1232
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Yu Kongtong¹²³⁴,Zhou Yulin¹²³⁴,Li Yuhuan¹²³⁴,Sun Xiangshi¹²³⁴,Sun Fengying¹²³⁴,Wang Xinmei¹²³⁴,Mu Hongyan¹²³⁴,Li Jie¹²³⁴,Liu Xiaoyue¹²³⁴,Teng Lesheng¹²³⁴,Li Youxin¹²³⁴

Affiliation:

1. School of life sciences

2. Jilin University

3. Changchun

4. People's Republic of China

Abstract

We developed an improved pre-conjugation strategy, in which herceptin as a ligand was pre-conjugated with DSPE-PEG2000-Mal via chemical cross-linking, followed by conjugation onto the surface of pre-prepared paclitaxel-loaded PLGA/DODMA nanoparticles through hydrophobic interaction and electrostatic attraction for paclitaxel delivery.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2016/BM/C6BM00308G

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