Non-viral nanocarriers for intracellular delivery of microRNA therapeutics

Author:

Bai Zhiman1234,Wei Jing56784,Yu Changmin56784ORCID,Han Xisi56784,Qin Xiaofei56784,Zhang Chengwu56784,Liao Wenzhen910111213,Li Lin56784ORCID,Huang Wei56784

Affiliation:

1. School of Physics and Materials Science

2. Anhui University

3. Hefei 230601

4. China

5. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM)

6. Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM)

7. Nanjing Tech University (NanjingTech)

8. Nanjing 211816

9. Department of Nutrition and Food Hygiene

10. Guangdong Provincial Key Laboratory of Tropical Disease Research

11. School of Public Health

12. Southern Medical University

13. Guangzhou 510515

Abstract

MicroRNAs are small regulatory noncoding RNAs that regulate various biological processes. Herein, we will present the development of the strategies for intracellular miRNAs delivery, and specially focus on the rational designed routes, their mechanisms of action, as well as potential therapeutics used in the host cells orin vivostudies.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Anhui Province

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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