Real-time monitoring and inhibition of the activity of carbapenemase in live bacterial cells: application to screening of β-lactamase inhibitors
Author:
Affiliation:
1. Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education
2. Chemical Biology Innovation Laboratory
3. College of Chemistry and Materials Science
4. Northwest University
5. Xi’an 710127
Abstract
Antibiotic resistance mediated by β-lactamases including metallo-β-lactamases (MβLs) has become an emerging threat.
Funder
Natural Science Foundation of Shaanxi Province
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ03475D
Reference40 articles.
1. New β-lactam antibiotics and β-lactamase inhibitors
2. An update on β-lactamase inhibitor discovery and development
3. Proliferation and significance of clinically relevant β-lactamases
4. Metallo-β-lactamases: a last frontier for β-lactams?
5. A New Approach to the Inhibition of Metallo-β-lactamases
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1. A practical electrochemical method for determining the inhibitory activity of New Delhi Metallo-β-lactamase-1 inhibitors;Microchemical Journal;2023-12
2. Inhibiting the metallo-β-lactamases: challenges and strategies to overcome bacterial β-lactam resistance;Future Medicinal Chemistry;2022-07
3. Nanomaterial-Based Zinc Ion Interference Therapy to Combat Bacterial Infections;Frontiers in Immunology;2022-06-30
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