Transition metal-free approach for late-stage benzylic C(sp<sup>3</sup>)–H etherifications and esterifications-Reference-Cited by-同舟云学术

Transition metal-free approach for late-stage benzylic C(sp³)–H etherifications and esterifications

Published:2022 Issue:81 Volume:58 Page:11454-11457
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhang Yu¹,Sahoo Prakash Kumar¹,Ren Peng¹,Qin Yuman¹,Cauwenbergh Robin¹^ORCID,Nimmegeers Philippe²³,SivaRaman Gandhi⁴^ORCID,Van Passel Steven²⁵,Guidetti Andrea⁶,Das Shoubhik¹^ORCID

Affiliation:

1. ORSY Division, Department of Chemistry, Universiteit Antwerpen, Campus Groenenborger, Groenenborgerlaan 171, 2020 Antwerpen, Belgium

2. Department of Engineering Management, Universiteit Antwerpen, Prinsstraat 13, 2000, Antwerpen, Belgium

3. Intelligence in Processes, Advanced Catalysts and Solvents (iPRACS), Faculty of Applied Engineering, Universiteit Antwerpen, Groenenborgerlaan 171, 2020 Antwerpen, Belgium

4. Department of Chemistry, Gandhigram Rural Institute, Gandhigram, 624032, Tamilnadu, India

5. Nanolab Centre of Excellence, Prinsstraat 13, 2000, Antwerpen, Belgium

6. Biophysics and Biomedical Physics (BIMEF), Department of Chemistry, University of Antwerp, B2610 Antwerp, Belgium

Abstract

Herein, we report a transition metal-free approach for the regioselective functionalisation of benzylic C(sp3)–H bonds using alcohols and carboxylic acids as the nucleophiles. Late stage functionalization has been done with complex drug molecules.

Funder

Fonds Wetenschappelijk Onderzoek

Universiteit Antwerpen

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC02661A

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