Discovery of novel tubulin CBSI <b>(<i>R</i>)-9k</b> from the indanone scaffold for the treatment of colorectal cancer-Reference-Cited by-同舟云学术

Discovery of novel tubulin CBSI (R)-9k from the indanone scaffold for the treatment of colorectal cancer

Published:2023 Issue:12 Volume:14 Page:2738-2750
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Huo Zhipeng¹,Min Delin¹,Zhang Shijie¹,Tang Mei-Lin¹,Sun Xun¹²^ORCID

Affiliation:

1. Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China

2. The Institutes of Integrative Medicine of Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China

Abstract

Compared with the first line therapy 5-fluorouracil, (R)-9k bound to the colchicine site and showed more potent inhibitory activities against colorectal cancer cells, lower cytotoxicity against normal cells and less cardiotoxicity.

Funder

National Natural Science Foundation of China

Shanghai Municipal Commission of Economy and Informatization

Science and Technology Commission of Shanghai Municipality

Shanghai Science and Technology Development Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00337J

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