Molecular mechanism of phosphoinositides' specificity for the inwardly rectifying potassium channel Kir2.2-Reference-Cited by-同舟云学术

Molecular mechanism of phosphoinositides' specificity for the inwardly rectifying potassium channel Kir2.2

Published:2018 Issue:44 Volume:9 Page:8352-8362
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Meng Xuan-Yu¹²³⁴⁵,Kang Seung-gu⁶⁷,Zhou Ruhong¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Radiation Medicine and Protection

2. School for Radiological and Interdisciplinary Sciences (RAD-X)

3. Collaborative Innovation Centre of Radiation Medicine of Jiangsu Higher Education Institutions

4. Soochow University

5. Suzhou 215123

6. IBM Thomas J. Watson Research Center

7. USA

Abstract

We investigated the binding mechanism of PI(4,5)P₂ and variants on the inwardly rectifying potassium channel, Kir2.2. Our results not only demonstrated the molecular origin for their binding specificity, but also revealed the major driving forces.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC01284A

Reference44 articles.

1. CYTOPLASMIC ATP-DEPENDENT REGULATION OF ION TRANSPORTERS AND CHANNELS: Mechanisms and Messengers

2. The Complex and Intriguing Lives of PIP 2 with Ion Channels and Transporters

3. Regulation of cardiac inwardly rectifying potassium channels by membrane lipid metabolism

4. Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

5. Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): Interaction with other regulatory ligands

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