Matrix metalloproteinase-2-targeted superparamagnetic Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes for dual-mode imaging and photodynamic therapy

Author:

Duan Meng12345,Xia Fangfang12345,Li Tianliang12345,Shapter Joseph G.6789ORCID,Yang Sheng12345,Li Yongying12345,Gao Guo12345ORCID,Cui Daxiang12345ORCID

Affiliation:

1. Institute of Nano Biomedicine and Engineering

2. Key Laboratory for Thin Film and Micro Fabrication of the Ministry of Education

3. Department of Instrument Science and Technology

4. School of Electronic Information and Electrical Engineering

5. Shanghai Jiao Tong University

6. Australian Institute of Bioengineering and Nanotechnology (AIBN)

7. University of Queensland

8. St Lucia

9. Australia

Abstract

A novel matrix metalloproteinase 2-targeted superparamagnetic nanoprobes for MRI, NIR and photodynamic therapy of tumors have been developed. The nanoprobes can significantly inhibit the tumor growth compared with PBS and free Ce6.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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