4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections-Reference-Cited by-同舟云学术

4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections

Published:2024 Issue:5 Volume:15 Page:1589-1600
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Barbieri Francesca¹^ORCID,Carlen Vincent²,Martina Maria Grazia¹^ORCID,Sannio Filomena³^ORCID,Cancade Sacha³,Perini Cecilia⁴^ORCID,Restori Margherita¹,Crespan Emmanuele⁴,Maga Giovanni⁴,Docquier Jean-Denis³^ORCID,Cagno Valeria²,Radi Marco¹^ORCID

Affiliation:

1. Dipartimento di Scienze degli Alimenti e del Farmaco (DipALIFAR), Università degli Studi di Parma, Viale delle Scienze, 27/A, 43124 Parma, Italy

2. Institute of Microbiology, University Hospital of Lausanne, University of Lausanne, 1011 Lausanne, Switzerland

3. Dipartimento di Biotecnologie Mediche, Università degli Studi di Siena, Viale Bracci 16, 53100 Siena, Italy

4. Institute of Molecular Genetics IGM-CNR “Luigi Luca Cavalli-Sforza”, Via Abbiategrasso 207, I-27100 Pavia, Italy

Abstract

Is magic trifluoromethyl a thing? Replacing 4-CH3 with 4-CF3 in bithiazoles, allowed to identify broad antimicrobial agents active against multiple viruses and also against Gram-positive/negative bacteria.

Funder

Cystic Fibrosis Foundation

Novartis Foundation

Associazione Italiana per la Ricerca sul Cancro

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00686G

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