Identification of dabigatran etexilate major degradation pathways by liquid chromatography coupled to multi stage high-resolution mass spectrometry-Reference-Cited by-同舟云学术

Identification of dabigatran etexilate major degradation pathways by liquid chromatography coupled to multi stage high-resolution mass spectrometry

Published:2015 Issue:56 Volume:5 Page:45068-45081
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Amrani Fatma¹²³⁴⁵,Secrétan Philippe-Henri¹²³⁴⁵,Sadou-Yayé Hassane¹²³⁴⁵,Aymes-Chodur Caroline¹²³⁴⁵,Bernard Mélisande¹²³⁴⁵,Solgadi Audrey¹²⁶⁴⁵,Yagoubi Najet¹²³⁴⁵,Do Bernard¹²³⁴⁵

Affiliation:

1. Université Paris-Saclay

2. UFR de Pharmacie

3. Groupe Matériaux et Santé

4. Institut d'Innovation Thérapeutique

5. 92296 Châtenay-Malabry

6. SAMM – Service d'Analyse des Médicaments et Métabolites

Abstract

The major degradation mechanisms of dabigatran etexilate were deduced in the context of stress testing. Under hydrolytic stress conditions, O-dealkylation may occur along with formation of benzimidic acid derivatives.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA04251H

Reference21 articles.

1. 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary

2. Dabigatran Etexilate: An Oral Direct Thrombin Inhibitor for the Management of Thromboembolic Disorders

3. Meta-Analysis of Efficacy and Safety of New Oral Anticoagulants (Dabigatran, Rivaroxaban, Apixaban) Versus Warfarin in Patients With Atrial Fibrillation

4. Dabigatran: Review of Pharmacology and Management of Bleeding Complications of This Novel Oral Anticoagulant

5. S. W. Baertschi , K. M.Alsante and R. A.Reed, in Pharmaceutical stress testing: predicting drug degradation, Informa Healthcare, New York, 2nd edn, 2011, ch. 2, pp. 10–49

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Physicochemical investigation of a novel curcumin diethyl γ-aminobutyrate, a carbamate ester prodrug of curcumin with enhanced anti-neuroinflammatory activity;PLOS ONE;2022-03-18

2. Application of PAT-Based Feedback Control Approaches in Pharmaceutical Crystallization;Crystals;2021-02-24

3. Novel semibatch supersaturation control approach for the cooling crystallization of heat‐sensitive materials;AIChE Journal;2020-03-06

4. Gradient RP-HPLC method for the determination of potential impurities in dabigatran etexilate in bulk drug and capsule formulations;Arabian Journal of Chemistry;2019-12

5. Model-Based Optimization of Cooling Crystallization of Active Pharmaceutical Ingredients Undergoing Thermal Degradation;Crystal Growth & Design;2019-04-17