A highly efficient Suzuki–Miyaura methylation of pyridines leading to the drug pirfenidone and its CD3 version (SD-560)-Reference-Cited by-同舟云学术

A highly efficient Suzuki–Miyaura methylation of pyridines leading to the drug pirfenidone and its CD3 version (SD-560)

Published:2017 Issue:21 Volume:19 Page:5046-5053
ISSN:1463-9262
Container-title:Green Chem.
language:en
Short-container-title:Green Chem.

Author:

Falb Eliezer¹²³⁴⁵^ORCID,Ulanenko Konstantin¹²³⁴⁵,Tor Andrey¹²³⁴⁵,Gottesfeld Ronen¹²³⁴⁵,Weitman Michal⁶⁷⁸⁵,Afri Michal⁶⁷⁸⁵,Gottlieb Hugo⁶⁷⁸⁵,Hassner Alfred⁶⁷⁸⁵

Affiliation:

1. Discovery & Product Development

2. Global Innovative R&D

3. Teva Pharmaceutical Industries Ltd.

4. 42504 Netanya

5. Israel

6. Department of Chemistry

7. Bar-Ilan University

8. Ramat Gan 52900

Abstract

The first methylation/deuteromethylation in green and nearly quantitative Suzuki–Miyaura routes to pirfenidone and its d₃ analog SD-560, at 99% isotopic purity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/GC/C7GC01740E

Reference47 articles.

1. Pyridine elaboration through organometallic intermediates: regiochemical control and completeness

2. Regioselective reactions of 3,4-pyridynes enabled by the aryne distortion model

3. Pirfenidone: A Review of Its Use in Idiopathic Pulmonary Fibrosis

4. Green Chemistry: Principles and Practice

5. Seven Important Elements for an Effective Green Chemistry Program: An IQ Consortium Perspective

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