The effect of linker DNA on the structure and interaction of nucleosome core particles

Author:

Huang Yen-Chih1234ORCID,Su Chun-Jen5674,Korolev Nikolay891011,Berezhnoy Nikolay V.89101112ORCID,Wang Sai891011,Soman Aghil891011,Chen Chun-Yu5674,Chen Hsin-Lung1234ORCID,Jeng U-Ser5674ORCID,Nordenskiöld Lars891011

Affiliation:

1. Department of Chemical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters

2. National Tsing Hua University

3. Hsin-Chu 30013

4. Taiwan

5. National Synchrotron Radiation Research Center

6. Hsinchu Science Park

7. Hsinchu 30076

8. School of Biological Sciences

9. Nanyang Technological University

10. Singapore 637551

11. Singapore

12. Singapore Center for Environmental Life Sciences Engineering

Abstract

Small angle X-ray scattering reveals linker DNA-induced partial unwrapping of nucleosomal DNA on the nucleosome core particle (NCP) and the impact on NCP interaction demonstrating the crucial role of linker DNA.

Funder

Ministry of Science and Technology, Taiwan

Ministry of Education - Singapore

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

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