Taurocholic acid ameliorates hypertension through the activation of TGR5 in the hypothalamic paraventricular nucleus-Reference-Cited by-同舟云学术

Taurocholic acid ameliorates hypertension through the activation of TGR5 in the hypothalamic paraventricular nucleus

Published:2024 Issue:9 Volume:15 Page:5088-5102
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Li Ying¹²³⁴^ORCID,Gao Ya-Nan¹²³⁴,Zhu Ying-Bao⁵,Lu Wen-Fang⁵,Yu Jia-Yue¹²³⁴,Dong Yuan-Yuan¹²³⁴,Xu Meng-Yue⁶,Peng Bo¹²³⁴,Wu Jun-Zhe¹²³⁴,Su Qing¹²³⁴,Bai Juan⁷,Shi Xiao-Lian⁸,Kang Yu-Ming¹²³⁴,Li Hong-Bao¹²³⁴^ORCID,Xu Meng-Lu⁹

Affiliation:

1. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China

2. Institute of Cardiovascular Sciences, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China

3. Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China

4. Cardiometabolic Innovation Center, Ministry of Education, Xi'an, Shaanxi 710061, China

5. College of Acupuncture and Moxibustion, Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, 712000, China

6. The Second Clinical College of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China

7. Department of Anesthesiology, Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China

8. Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China

9. Department of Nephrology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, China

Abstract

Insufficient TCA may contribute to the pathogenesis of hypertension. PVN supplementation of TCA can activate TGR5 in neurons and microglia, downregulate inflammatory responses, suppress oxidative stress, and eventually ameliorate hypertension.

Funder

Natural Science Foundation of Shaanxi Province

Education Department of Shaanxi Province

Xi’an Jiaotong University

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D4FO00808A

Reference43 articles.

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2. Glutamatergic Inputs in the Hypothalamic Paraventricular Nucleus Maintain Sympathetic Vasomotor Tone in Hypertension

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