Protein precoating modulates biomolecular coronas and nanocapsule–immune cell interactions in human blood

Author:

Li Shiyao1ORCID,Ju Yi12ORCID,Zhou Jiajing1ORCID,Faria Matthew3,Ang Ching-Seng4ORCID,Mitchell Andrew J.5,Zhong Qi-Zhi1,Zheng Tian5,Kent Stephen J.6,Caruso Frank1ORCID

Affiliation:

1. Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia

2. School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia

3. Systems Biology Laboratory, School of Mathematics and Statistics, and the Department of Biomedical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia

4. Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia

5. Department of Chemical Engineering, Materials Characterisation and Fabrication Platform, The University of Melbourne, Parkville, Victoria 3010, Australia

6. Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia

Abstract

We demonstrate the effects of protein precoating on biomolecular corona formation and immune cell interactions of metal–phenolic network nanocapsules using proteomics analyses and human blood assays.

Funder

Australian Research Council

National Health and Medical Research Council

University of Melbourne

RMIT University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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