Combinatorial synthesis of substituted pyrazolo-fused quinazolines by the Rh(<scp>iii</scp>)-catalyzed [5 + 1] annulation of phenyl-1<i>H</i>-pyrazol-5-amine with alkynoates and alkynamides-Reference-Cited by-同舟云学术

Combinatorial synthesis of substituted pyrazolo-fused quinazolines by the Rh(iii)-catalyzed [5 + 1] annulation of phenyl-1H-pyrazol-5-amine with alkynoates and alkynamides

Published:2024 Issue:33 Volume:22 Page:6841-6846
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Chiu Wei-Jung¹,Chu Ting-Yen²,Sun Chung-Ming¹³^ORCID

Affiliation:

1. Department of Applied Chemistry, 1001 Ta-Hseuh Road, National Yang-Ming Chiao-Tung University, Hsinchu 300-10, Taiwan

2. Department of Biological Science & Technology, 1001 Ta-Hseuh Road, National Yang Ming Chiao Tung University, Hsinchu 300-10, Taiwan

3. Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, Kaohsiung 807-08, Taiwan

Abstract

A Rh(iii)-catalyzed C–H activation/cyclization cascade is developed for the first divergent synthesis of pyrazolo[1,5-a]quinazolines through a [5 + 1] annulation reaction exclusively.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00516C

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