Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene-Reference-Cited by-同舟云学术

Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene

Published:2020 Issue:10 Volume:18 Page:1968-1977
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zheng Xirong¹²³⁴⁵,Chen Xiabin¹²³⁴⁵,Zhang Ting¹²³⁴⁵,Zhan Max¹²³⁴⁵,Zhan Chang-Guo¹²³⁴⁵,Zheng Fang¹²³⁴⁵

Affiliation:

1. Molecular Modeling and Biopharmaceutical Center and Department of Pharmaceutical Sciences

2. College of Pharmacy

3. University of Kentucky

4. Lexington

5. USA

Abstract

Combined computational, in vitro and in vivo studies have consistently revealed that two cocaine hydrolases engineered from human butyrylcholinesterase can efficiently catalyze the hydrolysis of the most toxic cocaine metabolite norcocaethylene.

Funder

National Institute on Drug Abuse

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02762A

Reference68 articles.

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