The effect of histidine behaviors on the structural properties of Aβ(1–42) peptide in protonation stage one, two, and three

Abstract

The structural properties and aggregation tendency of Aβ(1–42) are significantly influenced by the protonation behavior of histidine. Notably, the (pεε), (pεp), and (ppp) forms exhibit high averaged β-sheet contents with three-strand structures.